Carl read the papersWhat it actually is
GHRP-2 (pralmorelin) is a second-gen GHRP that fires a GH pulse via the ghrelin receptor.
Users report far less appetite than with GHRP-6, making it the recomp/cutting choice, though a lab study still found it raised food intake.
How it’s thought to work
- Ghrelin agonist — GHS-R1a → endogenous GH pulse.
- Milder appetite — less hunger than GHRP-6 by user reports (it still raised food intake about 36% in a lab study).
- GHRH synergy — strong stacked with CJC/Mod-GRF.
- Cortisol/prolactin — dose-dependent, small rises in human studies.
What the research says
Approved in Japan (2004) only as a diagnostic GH-stimulation test; some human PK data. Performance dosing is anecdotal. Not approved as a treatment anywhere, WADA-banned.
- Clean GH pulse, less hunger (reported).
- Recomp / cutting favourite.
- Stacks with a GHRH.
Watch: GHRP-2 explained
Video by NuLife Peptides on YouTube. Not affiliated with Peptide Carl and not an endorsement — included because a second explanation of the same mechanism is often what makes it click.
Reported protocols
These are the doses the peptide community actually reports running (Reddit & forums), alongside published research — logged for education, not as a recommendation to use.
| Parameter | Commonly reported range |
|---|---|
| Community dose | 100 mcg per shot (saturation); higher only when stacked |
| Frequency | 2–3× daily |
| Route | SubQ (IM also used) |
| Cycle | 8–12 wks on, ~4 off to avoid desensitization |
| Community tip | GHRP-2 for cutting, GHRP-6 for bulking; run with CJC/Mod-GRF |
Common use cases
| Goal | Community protocol notes |
|---|---|
| Cutting / recomp | 100 mcg 2–3×/day fasted |
| GH pulse | stacked with CJC-1295/Mod-GRF |
| Sleep / recovery | a pre-bed dose |
Mixing it (reconstitution)
Freeze-dried peptides must be reconstituted with bacteriostatic water before they can be measured. Carl’s calculator turns “mg in the vial + ml of water + target dose” into “units on the syringe” — and tells you how long the vial lasts.
→ Open the Reconstitution Calculator
Injection & handling
SubQ (or IM), 100 mcg fasted, 2–3×/day; wait 20–30 min to eat. Commonly co-drawn with CJC-1295/Mod-GRF in the same shot. Refrigerate reconstituted.
Stacks it appears in
- GH pulse combo — GHRP-2 + CJC-1295 — the cleaner, cutting version of the pulse.
Sources
- KEGG DRUG D02040: pralmorelin (GHRP, Kaken), Japan diagnostic, approved 22 Oct 2004
- GHRP-2 test for adult GH deficiency, Eur J Endocrinol 2007 (PMID 17609397)
- GHRP-2 increases food intake in healthy men, J Clin Endocrinol Metab 2005 (PMID 15699539)
- GHRP-2 pharmacokinetics in children, J Clin Endocrinol Metab 1998 (PMID 9543135)
- GHRP-2 vs hexarelin: GH, prolactin, ACTH, cortisol in man, Peptides 1997 (PMID 9285939)
- WADA 2026 Prohibited List, S2.2.4 (GHRP-2, pralmorelin)
- FDA compounding safety list (Category 2), Apr 2026
